Single-Use Centrifuges

Benefits of Single-Use Systems

Optimize Product Recovery and Scalability


Since 2009, CARR Biosystems has been providing single-use separation systems to biopharma companies seeking low-shear separation, high-recovery performance, and fast processing time. Avoid the expense and waste of CIP/SIP stainless steel centrifuges and step up to the scalable, industry-leading, UniFuge platform.

More Data in Less Time

  • Get more data in less time while lowering costs. Our smallest scale UniFuge technology - UFMicro - requires minimal cell culture volume and technician time.
  • Optimize your process performance when developing process CTQs with low-shear separation and remarkably high processing speed.

Scale-up Seamlessly with UniFuge

  • De-risk Process Scaling: Establish easily transferable CTQs as you pass clinical milestones.
  • Optimize product quality via tunable process settings (flow, force).
  • Processing volumes to support you from process development to commercial manufacturing:
UFMicroUFMiniPilot ShallowPilot StandardU2K
Min Proc Vol70 ml270 ml1 L1.8 L10 L
Max Proc Vol25 L25 L500 L500 L2000+ L

Unsurpassed Performance

  • Optimize separation performance with best-in-class low-shear separation ensuring:
    • High cell viability for cell therapy and cellular agriculture applications
    • Isolation of antibodies from cell culture supernatant
    • Reduction of BSA levels well below the required minimum
  • Achieve high processing speeds without sacrificing the separation efficiency needed for demanding applications

With a small footprint, UniFuge systems are easy to operate, simplify training and require fewer staff than traditional centrifuges. 

  • 100% closed system
  • Low shear
  • Clear center
  • Reduce filtration needs by 85%
  • Set up and change over within 15 min
  • Cell viability up to 98%
  • Yield up to 98%
  • Confidently scale up to the U2k® or scale down to the UFMini®
  • Variable speed up to 4,000 x g
  • Reduce HCP and other contaminants
  • GMP-compliant data trail 21cfrPart11
  • Extractables data available



Want to learn more about the performance of single-use centrifuges from CARR Biosystems? Review whitepapers, case studies, and more here.

Key Features

Advantages of Single-Use Centrifuges

Easy-to-use, reliable equipment that delivers high product recovery.


Our proven low-shear technology boasts up to 98% yield and 98% or higher typical cell viability.


Our equipment can be used from development to commercial licensure and across different reactor volumes.

Ease of Use

Our machines are rapid to install and simple to operate.

Small Footprint

Our single-use centrifuges have a small footprint.

The UniFuge Family

Our Single-Use Centrifuges

The scalable UniFuge family of centrifuges has a variable g-force up to 4,000 x g. They employ gamma-irradiated sterile single-use modules, reducing the risk of contamination.


Mar 13, 2023, 16:53 PM
Title : UFMini®
Heading : UFMini® Single-Use Centrifugation
Listing description : The UFMini boasts a small footprint, with either 70 mL or 300 mL bowl and a flow rate of 29-1,000 mL/min.
Order : 1

Single-Use System

The UFMini is a single-use centrifuge designed for primary clarification of mammalian cell cultures (i.e., CHO cells), and harvesting (washing & concentrating) stem cells and other types of cells for biotechnology and pharmaceutical applications. This user-friendly system is the scaled-down version of our successful UniFuge® single-use centrifuge. The UFMini is intended for use in cleanrooms, in laminar flow hoods, and on benchtops.

  • Bowl capacities: Choose from 70 mL Micro or 300 mL Mini
  • Flow rate from 29-1,000 mL/min
  • Small footprint: Centrifuge Enclosure 69 cm x 56 cm x 38 cm (27” x 22” x 15”)
  • Easy to handle: Total skid weight of ~40 kg (90 lbs)
  • Gamma-irradiated single-use modules
  • Processes scalable to UniFuge® Pilot and U2k®
Compact Size

Small footprint is perfect for early-stage process development, ​​process characterization and small volume commercial production.

Confidently Scale Up

Accurately transferring operating protocols to the UniFuge® or U2k® is straightforward as you move from early-stage development to commercial manufacturing.

Streamline Processes

Uses a sterile single-use module that is easy to install and replace after each run.


Low-shear centrifugation allows for high-quality and high-recovery separation.

Save Time

Easily incorporated into a fully-automated workflow and significantly reduces processing time.


Software and automation minimize process upsets and errors.

Minimize Contamination Risks

This single-use, closed system reduces contamination risks. It provides flexibility for multi-product facilities.


The UniFuge systems are designed to resume and recover from an interrupted process without product loss.

Cell Washing

The UniFuge systems can hold materials in the bowl for washing and buffer exchanges.


Built in a state-of-the art US facility, following the highest standards of quality control.

  • Flow rate from 29-1000 mL/min
  • Processing up to 1 L/min
  • Variable speed up to 4,000 x g
  • Designed for fluid transfer with temperatures in the range of 4-38 °C (39-100 °F)
  • Optional data acquisition for SCADA System via Ethernet connection
  • cGMP-compliant 21 CFR Part 11 data trail
  • Low noise level (below 80 dB) during operation
  • Instrument built in a state-of-the-art ISO 9001 US facility, following the highest standards of quality control.
  • Fully-automated, intuitive software
  • PLC color touchscreen
  • Includes RFID system for module diagnostic monitoring and recording
Single-use Modules
  • Bowl capacities: Choose from 70mL or 300mL
  • Lightweight single-use module with integral tube set
  • Predictable supply chain with multiple manufacturing facilities in the United States
  • Gamma-irradiated
  • Extractables data available
  • Continuous discharge of supernatant and intermittent discharge of cell culture
  • Modules can be tube-welded to single-use bioreactor connections. Customer-specified single-use connectors are available upon request.
  • RFID tag (gamma irradiated) retains the module manufacturing data and communicates with the UFMini to capture metrics including runtime, previous alarms, integrity test results, and more.
How It Works

The UFMini is completely automated with flexible cycle parameters. The feed suspension is gently pumped to the separation zone of the single-use module and the cells centrifugally settle to the outer radius, while the clarified supernatant is continuously discharged. Once the user-programmed cycle timer has expired, the controller stops the rotor and discharges the cells. This cycle automatically repeats for a user-selectable number of cycles, based upon bioreactor volume.

Automation and General Specifications
  • Allen Bradley® PLC
  • Allen Bradley® HMI Touchscreen 22.9 cm (9”) - 16:9 aspect ratio
  • Fluid connections on left front side of machine; utility connections on right side
  • High cell density
  • PCV up to 25%
Utility Requirements
  • Power configuration: Single phase universal power supply 100 to 240 volts, 50/60 Hz, suitable for global use, including:
    • US: 120V/60 Hz, 6.3 A
    • Europe: 230V/50 Hz, 3.1 A
    • Japan: 100V/60 Hz/50 Hz, 7.5 A
  • Pneumatic: Clean, dry air supply 4.5-6.6 bar (65-95 psi), 57 SLPM (2 SCFM)
Single-Use Module
  • 300 mL single-use module with 6 mm (1/4”) ID and 9.5 mm (3/8”) OD Silicone tubing
  • Continuous discharge of supernatant and intermittent discharge of cell culture
  • Center feed for low-shear operation
  • Concentric tubes to introduce feed and remove supernatant
testimonials7 Single-Use Centrifuges Brochure
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