UFMini®: A Single-Use System for Scale-Down Studies
Obtain high cell recovery in small-to-mid-scale processing with the UniFuge Mini. Designed for high cell viability, it utilizes tubular bowl centrifugation for quicker iterations and testing, accelerating development through to pilot and large-scale production.
| Minimum Working Volume 90 mL or 275 mL | Flow Rate 50-1000 mL/min | G-force Up to 4,000 xg |
Benefits of CARR Biosystems UniFuge Mini
Versatility
Perform diverse cell processing operations, including harvest, media exchange, concentration, and cell washing, in one powerful device.
Performance
Maximize yield with low-shear tubular bowl centrifugation, enhancing cell viability and recovering more product from less culture volume.
Efficiency
Streamline cell processing with intuitive software and full automation, reducing operational costs and enhancing process intensification.
Feasibility
De-risk development by conducting scale-down studies before investing in large-scale production, with consistent, reliable results from the smallest UniFuge.
Need more versatility?
The UniFuge Mini centrifuge has two module size options. The Micro module enables smaller volume processing at a reduced flow rate, and the Mini module offers a larger discharge volume. Choose the module that supports the desired concentration factor and intended application.
The UniFuge Mini is a user-friendly, automated batch centrifuge for low-shear separation of mammalian, bacterial, and insect cell lines. This scaled-down version of the UniFuge Pilot is perfect for cleanrooms, laminar flow hoods, and benchtops. It features a single-use module (rotor and separation chamber) and integral tube set that comes pre-gamma irradiated to ensure easy installation, clean-up, and disposal, making it ideal for de-risking scale-down studies before transitioning to larger-scale bioprocesses.
- Low noise level (below 80dB) during operation
- Continuous discharge of supernatant and intermittent discharge of cell culture
- Reduces host cell proteins and other contaminants
- Compatible with various processing volumes and concentration targets
- Designed for fluid transfer with temperatures in the range of 4-38 °C (39-100 °F)
- Includes radio frequency identification tag (RFID) system for module diagnostic monitoring and recording
- Available in two minimum working volume options: Micro (90mL) or Mini (300mL)
| Rec. Processing Volume | Micro - 0.5- 10L Mini - 5L - 25L |
| Max Flow Rate | 50 - 1000mL/min |
| Rotational Force | 300 to 4,000 x g |
| Weight | 45 kg (100 lbs) |
| Maximum Case Pressure | 4.5-6.6 bar (65-95 psi) |
| Programmable Logic Controllers (PLC) | Allen-Bradley® |
| Feed | Center for low-shear operation |
| Power Configurations | Single-phase universal power supply 100 to 240 volts, 50/60 Hz, suitable for global use |
| Pneumatic | Clean, dry air supply 4.5-6.6 bar (65-95 PSI), 57 Standard Liters per Minute (SLPM), 2 Standard Cubic Feet per Minute (SCFM) |
Balancing centrifugal forces and fluid flow rates, the UniFuge cell processing platform gently concentrates cells in the tubular bowl while the supernatant (cell-free media or buffer) flows into a collection chamber. The concentrated cells can then be washed or exchanged with another medium or buffer within the same closed chamber. Once the module fills with cells, the controller stops the rotor to automatically collect the cell concentrate. This cycle repeats until cell processing is complete.
The UniFuge Mini features:
- Fully automated, intuitive software accessible through a PLC color touchscreen and HMI Touchscreen 22.9 cm (9”) - 16:9 aspect ratio
- Four pinch valve configuration: Feed, Concentrate, Supernatant, and Buffer
- CE Compliant Design
- Benchtop footprint
- Optional Supervisory Control and Data Acquisition (SCADA) via Ethernet connection
- cGMP compliance with standards, including Federal Regulations (21 CFR Part 11) data trail
Endorsements
See What People Are Saying About Our Single-Use Centrifuges
“The UniFuge line is easy to scale-up to the U2k or down to the UFMini.”
mAbs Bioproduction Expert
“The UniFuge was fairly simple to use and scaled nicely from the UFMini.”
Cell Therapies Bioproduction Expert
“The UniFuge has higher g forces and flow rates [compared to competitive offerings].”
Viral Vector Bioproduction Expert, HEK
"[The UniFuge line] is scalable, easier to operate, and my process yield is better than using depth filters."
Protein Separation Bioproduction Expert, CHO
Scale up or down with UniFuge®
Our UniFuge cell processing platform enables low-shear separation and improves cell recovery throughout development and commercialization.
*Processing speeds are application dependent and may vary.
**Weights and dimensions are dependent on system configuration and options required.
Featured Resources
Frequently Asked Questions (FAQs)
Where does the UniFuge Mini fit into the bioprocessing workflow?
The UniFuge Mini fits into the bioprocessing workflow as a small-to-intermediate scale solution for cell clarification and harvesting. With the option to choose the Micro or Mini module, it is ideal for early-stage process development and optimization, bridging the gap between lab-scale experiments, pilot studies and large-scale manufacturing. Its ability to optimize and scale up processes ensures seamless transition and efficiency in cell recovery and viability across various stages of bioprocessing.
What types of cells can be processed using the UniFuge Mini?
The UniFuge Mini is suitable for processing various cell types, including mammalian, bacterial, insect, and plant cells. Its low-shear environment ensures high cell viability across different cell types, making it ideal for diverse research and development applications.
How does the UniFuge Mini ensure sterility during the cell processing workflow?
The UniFuge Mini uses single-use, gamma-irradiated modules that are endotoxin-free and free from animal-derived components. These modules ensure a sterile environment for each processing run, reducing the risk of contamination.
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