Viafuge ® V12

Product Overview

Clean-in-Place / Sterilize-in-Place System

The Viafuge® V12 is designed for fast, gentle medium- to large-scale cell harvesting and clarification. Capable of separating a wide variety of mammalian and insect cells with little to no damage, the Viafuge V12 offers high purity results with undetectable cell concentrations in clarified supernatant.

  • Bowl capacity: 9.6 L or 16.7 L
  • Flow rates up to 2400 L/hr for batches up to 2000 L
  • Footprint: ~ 127 cm wide x 249 cm deep x 287 cm high (50” x 98 ” x 113”)
  • Total weight ~ 1119 kg (2,460 lbs)
  • Gentle cell harvesting and supernatant recovery
  • scalableCan be scaled-down to smaller automated Pilot model
  • Improved product processing
  • Concentrated cells and supernatant can be recovered without breaking containment
  • 20-fold concentration factor

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Low-Shear Performance

The Viafuge V12’s unique design minimizes shear forces on cells, boasting a typical cell viability of 98% or higher and up to 98% yield.


Processes developed on the Viafuge® Pilot can be seamlessly scaled to the Viafuge V12.

  • Bowl capacity: 9.6 L or 16.7 L
  • Flow rates up to 2400 L/hr for batches up to 2000 L
  • Variable speeds up to 5000 x g
  • Sealed automatic operation
  • Fully-automated operation
  • Closed-system design with CIP/SIP
  • cGMP construction
  • ASME-rated designs available
  • Flexible optimization
  • Optional Hazardous Duty (Class 1, Div 1)  CE configurations are available
  • State-of-the-art manufacturing facility located in the United States
How It Works

Using an innovative design, the Viafuge V12 introduces feed through a stationary pipe, where it is accelerated to full rotational speed under low shear before entering the titanium-alloy bowl. Cells are then concentrated along a gentle path between the core and the bowl wall. The clarified supernatant is continuously discharged by gravity at atmospheric pressure. Periodically, the concentrated cells are automatically recovered from the Viafuge V12 for collection, and the cycle is repeated to process the remainder of the feed batch.

Automation and General Specifications
  • Allen Bradley® or Siemens® PLC
  • Allen Bradley® or Siemens® HMI touchscreen 30.7 cm (12.1”)
  • Maximum case pressure (for cooling) 6.9 bar (100 psi)
Utility Requirements
  • Power configuration: Three phase voltage supply:
    • US: 230V/60 Hz, 20 A
    • Europe: 200V/50 Hz, 20 A
    • Japan: 200V/60 Hz/50 Hz, 20 A
  • Optional: Others as needed
  • Pneumatic: Clean, dry air supply 6 bar (90 psi) at 1 SLPM
Process Wetted Parts Construction
  • USP Class VI components
    • 316L Stainless Steel
    • 17-4 PH Stainless Steel
    • Nitronic 60 Stainless Steel
    • Platinum cured silicone hoses
    • EPDM elastomers
    • Ti-6Al-4V Titanium


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