ViaFuge® Pilot: A Stainless Steel System for Gentle Cell Separation
Enhance early-stage bioprocessing with the ViaFuge® Pilot. Designed for gentle separation of shear-sensitive targets, this pilot-scale system preserves cell viability in small-scale, high-value production.
| Minimum Working Volume 1.3 L | Flow Rate 4 L/min | G-force Up to 10,000 xg |
Benefits of CARR Biosystems ViaFuge Pilot
Viability
Maximize recovery of viable cells with gentle processing, specifically designed for shear-sensitive materials. Ideal for applications involving CHO, SF9, Vero, MRC5, and other insect and mammalian cells.
Versatility
Easily adapt to diverse applications, including cell culture separations, media exchange, sterile operations, repeated batch processes, and process intensification, in both research and industrial settings.
Durability
Reduce downtime and maintenance costs with robust construction and high-quality materials designed for reliable performance and a longer operational lifespan.
Optimization
Streamline your development process, thoroughly evaluate and refine workflows, and optimize low-volume, high-value products before scaling up.
The ViaFuge Pilot is a light-duty tubular bowl centrifuge designed for gentle processing and complete liquid-solid separation. Operating at lower G-forces, it's ideal for efficiently separating shear-sensitive materials like mammalian and insect cells, flocculated proteins, and DNA.
- Complete liquid/liquid separations
- Simple operation, table-top design
- Integrated cooling jacket
Rec. Processing Volume | 25-500 L |
| Max Flow Rate | 4 L/min |
| Rotational Force | 500 - 10,000 xg |
| Max Concentrate Density | <1.5 g/ml |
| Weight (approx) | 113-136 kg (250-300 lbs) |
| Programmable Logic Controllers (PLC) | Allen-Bradley® |
| Feed | Center for low-shear operation |
Electrical Requirements | 120 V/60 Hz (US) or 230 V/50 Hz (EU) |
| Pneumatic | Instrument-quality air only, supplied at 275 ± 69 kPa (40 ± 10 psi) |
Process Wetted Parts Construction
- USP Class VI components
- 316L stainless steel
- Platinum-cured silicone process contact materials
- Ethylene propylene diene monomer (EPDM) elastomers
- Ti-6Al-4V titanium alloy
Using tubular bowl technology, the feed is introduced through a stationary pipe to the center of the titanium-alloy bowl. Centrifugal forces gently concentrate viable cells along the bowl wall, preserving cell health. Once the bowl fills with cell concentrate, the simple manifold system and pump recover cells.
The ViaFuge Pilot features:
- Fully automated, intuitive software accessible through Allen-Bradley or Siemens HMI touchscreen 30.7 cm (12.1”)
- Optional hazardous duty (Class 1, Div 1, Group C and D) and CE configurations available
- Designs available for SIP ASME- and PED-rated boundary and hazardous locations
Endorsements
See What People Are Saying About Stainless Steel Centrifuges
"Gentle handling of our cells at scale resulted in higher VLP recovery.”
Director of Operations, Vaccine Manufacturing
“We replaced our bottle centrifuges with a single continuous ViaFuge, saving cleaning, autoclaving, and manual manipulations."
Animal Vaccine Manufacturing Operations Manager
Scale up or down with ViaFugeⓇ
Our ViaFuge family enables efficient liquid-solid separation with durable stainless steel construction. It is designed to handle delicate mammalian and insect cells, proteins, and other shear-sensitive materials from pilot to large-scale applications.
*Processing speeds are application dependent and may vary.
**Weights and dimensions are dependent on system configuration and options required.
Featured Resources
Frequently Asked Questions (FAQs)
Is the ViaFuge Pilot scalable to larger production volumes?
Yes, while the ViaFuge Pilot is designed for pilot-scale and small-scale operations, the processes and results it achieves can be scaled up to the ViaFuge V12, for higher production volumes without compromising on performance.
How does the ViaFuge Pilot ensure complete liquid-solid separations?
The ViaFuge Pilot utilizes a solid tubular bowl design, which operates at lower speeds to minimize shear forces on cells. Centrifugal forces gently separate solids from liquids, concentrating cells along the bowl wall. This design ensures thorough and efficient liquid-solid separations.
What design and safety certifications are available for the ViaFuge Pilot?
The ViaFuge Pilot can be configured with various design and safety certifications to meet specific industry standards. Available options include CE Marking, which indicates compliance with European safety, health, and environmental requirements. Additionally, the ViaFuge Pilot can be designed to meet ASME/PED-rated configurations for CIP/SIP operations, ensuring that the system is safe and reliable for use in regulated environments that require high levels of safety.
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