PowerFuge® Pilot: A Stainless Steel System for High-Speed Bioseparation
Achieve robust liquid-solid separations in early-stage development and pilot-scale production with the PowerFuge Pilot tubular bowl centrifuge. Experience drier solids and clearer centrates with minimal maintenance and straightforward operation.
| Minimum Working Volume 1.1 L | Flow Rate 1 L/min | G-force Up to 20,000 xg |
Benefits of CARR Biosystems PowerFuge Pilot
Versatility
Transition from development to manufacturing, handling applications like E. coli harvest, lysate removal, P. pastoris clarification, specialty chemicals, and solvent separations.
Performance
Handle even the most challenging separations with the ability to process bacteria, fungi, proteins, and submicron particles using a tubular bowl centrifuge with 20,000xg separation force.
Durability
Reduce downtime and maintenance costs with robust construction, high-quality materials, and comprehensive maintenance, ensuring fewer parts to replace and longer operational life.
Optimization
Evaluate and refine your processes with pilot-scale capabilities for comprehensive testing and optimization before scaling up to cGMP, chemical, or pharmaceutical protocols.
The PowerFuge Pilot is designed for efficient liquid-solid separation with manual removal of solids. This imperforate tubular bowl centrifuge provides strong separating forces, enabling low-shear separation of bacterial, fungal, and protein particles. It offers higher cell recovery with a product yield of up to 98%.
- Complete liquid/solid separations
- Validation guides
- Table-top design
- Integrated cooling jacket
| Bowl Volume | 1.1 L |
| Max Flow Rate | Up to 1 L/min for batches up to 100 L |
| Rotational Force | Up to 20,000 xg |
| Max Concentrate Density | <1.5 g/ml |
| Weight | 91-113 kg (200-250 lbs) |
| Programmable Logic Controllers (PLC) | Allen-Bradley® |
| Feed | Feedcone acceleration |
| Electrical Requirements | 120 V/60 Hz (US) or 230 V/50 Hz (EU) |
Process Wetted Parts Construction
- USP Class VI components
- 316L stainless steel
- Nitronic 60 stainless steel
- Platinum-cured silicone process contact materials
- Ethylene propylene diene monomer (EPDM) elastomers
- Ti-6Al-4V titanium alloy
The PowerFuge is a continuous flow centrifuge that introduces the feed through a stationary pipe and accelerates it to full rotational speed before entering the titanium-alloy tubular bowl. Centrifugal forces separate solids from liquids, compressing solids against the bowl wall while the supernatant flows into a collection chamber. Compressed solids are periodically removed with a fully automated scraping cycle.
The PowerFuge Pilot features:
- Fully automated, intuitive software accessible through Allen-Bradley HMI touchscreen
- Optional hazardous duty (Class 1, Div 1, Group C and D) and CE configurations available
- Designs available for SIP ASME and PED rated boundary and hazardous locations
Endorsements
See What People Are Saying About Our Stainless Steel Centrifuges
“The explosion-proof PowerFuge closed up our solvent process for a safe and environmentally friendly manufacturing method.”
Senior Process Engineer, Pigments
“The PowerFuge closed up our ethanol process and its automatic scraping improved our recovery.”
Associate Director of Vaccine Franchise
“Removing large particles with PowerFuge reduced the number of filtration steps.”
Manufacturing Engineer, Pigments
“The high g-force of the PowerFuge [e. Coli lysate clarification] reduced our downstream clarification needs.”
Senior Process Development Scientist, pDNA
"Gentle handling of our cells at scale resulted in higher VLP recovery.”
Director of Operations, Vaccine Manufacturing
Scale up or down with PowerFugeⓇ
Our PowerFuge family enables efficient liquid-solid separation. Its durable stainless steel construction handles bacteria, fungi, proteins, and submicron particles from small to large-scale applications.
*Processing speeds are application dependent and may vary.
**Weights and dimensions are dependent on system configuration and options required.
Featured Resources
Frequently Asked Questions (FAQs)
How big is the PowerFuge Pilot and can it be moved easily?
The PowerFuge Pilot has a compact footprint of 91 cm wide x 61 cm deep x 76 cm high (36” x 24” x 30”) and weighs between 91-113 kg (200-250 lbs), making it suitable for benchtop use and relatively easy to move within a lab setting.
How does the PowerFuge Pilot handle temperature-sensitive materials?
The PowerFuge Pilot features an internal cooling jacket that helps maintain product temperatures from 2º C to 40º C, with internal cooling temperatures as low as -10º C, making it suitable for temperature-sensitive applications.
What are the key features of the PowerFuge Pilot that support efficient liquid-solid separation?
The PowerFuge Pilot tubular bowl centrifuge features centrifugal forces up to 20,000 x g, a contoured hand scraper for easy solid removal, and CIP/SIP capabilities, all designed to support efficient and reliable liquid-solid separation.
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