Product overview

Clean-in-Place / Sterilize-in-Place System

The Powerfuge P12 System is a batch liquid/solid separation system for bacteria, yeast, proteins and sub-micron particles. It is designed to provide continuous-flow two-phase separation of solids and liquids and meets cGMP and CE requirements as well as chemical and pharmaceutical industry protocols.

Bowl capacity: 8L
Flow rates up to 500 L/hr for batches up to 500 L
Footprint ~ 78.7 cm wide x 172.7 cm deep x 203.2 cm high (31” x 68” x 80”)
Total weight ~ 1924 kg (4,240 lbs)
Fully scalable to smaller automated Pilot and P6 models
Fully scalable to larger automated P18 model
Drier solids and clear liquids

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Performance

With g forces up to 20,000 X g, the Powerfuge addresses even the most challenging separations.

Scalability

The Powerfuge family of products can be used for small process development volumes all the way to very large commercial manufacturing, allowing for seamless scale-up and scale-down.

Versatility

The Powerfuge is designed to serve the needs of a variety of markets.

Features

Bowl capacity: 8 L
Flow rates up to 500 L/hr for batches up to 500 L
Variable speeds up to 20,000 g
Sealed automatic operation
Full CIP/SIP designs + automated CIP/SIP cycles
Meets cGMP and CE requirements
Designs available for ASME-rated boundary, hazardous locations, and aseptic operations
Continuous-flow two-phase separation
Optional hazardous duty (Class 1, Div 1) CE configurations are available
State-of-the-art manufacturing facility located in Clearwater, Florida USA

How It Works

Using an innovative design, the feed is introduced through a stationary pipe and accelerated to full rotational speed before entering the titanium-alloy bowl. In this system, centrifugal forces as 20,000 g permit separation of even sub-micron particles. Compressed solids are periodically removed with a fully automated scraping cycle. After the solids have been discharged, automated CIP/SIP cycles can be performed via the PLC-controlled operating sequence.

Automation and General Specifications

Allen-Bradley® or Siemens® PLC
Allen-Bradley or Siemens HMI touchscreen 30.7 cm (12.1”)
Maximum case pressure (for cooling) 6.9 bar (100 psi)

Utility Requirements

Power configuration: Single phase voltage supply:

US: 460V/60 Hz, 45 A
Europe: 400V/50 Hz, 46 A
Japan: 200V/60 Hz/50 Hz, 90 A

Optional: Others as needed
Pneumatic: Clean, dry air supply 6 bar (90 psi) at 566 SLPM (20 SCFM)

Process Wetted Parts Construction

316L Stainless Steel
17-4 PH Stainless Steel
Nitronic 60 Stainless Steel
Platinum-cured silicone hoses
EPDM elastomers
Ti-6Al-4V Titanium

Stainless Steel Centrifuges Brochure

Endorsements

See What People Are Saying About Our Equipment

“The UniFuge was easy to scale-up, and the Viafuge enables us to recover viable cells at large scale, beyond what single-use can typically accomplish.”

Cellular Agriculture Entrepreneur

“We replaced our bottle centrifuges with a single continuous Viafuge, saving cleaning, autoclaving, and manual manipulations."

Animal Vaccine Manufacturing Operations Manager

“Gentle handling of our cells at scale resulted in higher VLP recovery.”

Director of Operations, Vaccine Manufacturing

“The high g-force of the Powerfuge [e. Coli lysate clarification] reduced our downstream clarification needs.”

Senior Process Development Scientist, pDNA

“Removing large particles with Powerfuge reduced the number of filtration steps.”

Manufacturing Engineer, Pigments

“The Powerfuge closed up our ethanol process and its automatic scraping improved our recovery.”

Associate Director of Vaccine Franchise

“The explosion proof Powerfuge closed up our solvent process for a safe and environmentally friendly manufacturing method.”

mAbs Senior Process Engineer, Pigments