Single-Use Centrifuges

Benefits of Single-Use Systems

Optimize Product Recovery and Scalability


Since 2009, CARR Biosystems has been providing single-use separation systems to biopharma companies seeking low-shear separation, high-recovery performance, and fast processing time. Avoid the expense and waste of CIP/SIP stainless steel centrifuges and step up to the scalable, industry-leading, UniFuge platform.

More Data in Less Time

  • Get more data in less time while lowering costs. Our smallest scale UniFuge technology - UFMicro - requires minimal cell culture volume and technician time.
  • Optimize your process performance when developing process CTQs with low-shear separation and remarkably high processing speed.

Scale-up Seamlessly with UniFuge

  • De-risk Process Scaling: Establish easily transferable CTQs as you pass clinical milestones.
  • Optimize product quality via tunable process settings (flow, force).
  • Processing volumes to support you from process development to commercial manufacturing:
UFMicroUFMiniPilot ShallowPilot StandardU2K
Min Proc Vol70 ml270 ml1 L1.8 L10 L
Max Proc Vol25 L25 L500 L500 L2000+ L

Unsurpassed Performance

  • Optimize separation performance with best-in-class low-shear separation ensuring:
    • High cell viability for cell therapy and cellular agriculture applications
    • Isolation of antibodies from cell culture supernatant
    • Reduction of BSA levels well below the required minimum
  • Achieve high processing speeds without sacrificing the separation efficiency needed for demanding applications

With a small footprint, UniFuge systems are easy to operate, simplify training and require fewer staff than traditional centrifuges. 

  • 100% closed system
  • Low shear
  • Clear center
  • Reduce filtration needs by 85%
  • Set up and change over within 15 min
  • Cell viability up to 98%
  • Yield up to 98%
  • Confidently scale up to the U2k® or scale down to the UFMini®
  • Variable speed up to 4,000 x g
  • Reduce HCP and other contaminants
  • GMP-compliant data trail 21cfrPart11
  • Extractables data available



Want to learn more about the performance of single-use centrifuges from CARR Biosystems? Review whitepapers, case studies, and more here.

Key Features

Advantages of Single-Use Centrifuges

Easy-to-use, reliable equipment that delivers high product recovery.


Our proven low-shear technology boasts up to 98% yield and 98% or higher typical cell viability.


Our equipment can be used from development to commercial licensure and across different reactor volumes.

Ease of Use

Our machines are rapid to install and simple to operate.

Small Footprint

Our single-use centrifuges have a small footprint.

The UniFuge Family

Our Single-Use Centrifuges

The scalable UniFuge family of centrifuges has a variable g-force up to 4,000 x g. They employ gamma-irradiated sterile single-use modules, reducing the risk of contamination.

UniFuge® Pilot

May 17, 2023, 17:00 PM
Title : UniFuge® Pilot
Heading : UniFuge ® Pilot Single-Use Centrifugation
Listing description : The UniFuge Pilot is a mid-sized centrifuge with a 1.8 L bowl and a flow rate of 1-4 L/min.
Order : 2

Single-Use System

The UniFuge® Pilot uses a gamma-irradiated, single-use module to eliminate cleaning needs. It is designed for primary clarification of mammalian cell cultures (e.g., CHO cells), and harvesting (including washing and concentrating) stem cells and other types of cells for biotechnology and pharmaceutical applications.

  • Bowl capacity: 1.8 L
  • Flow rate from 1-4 L/min (higher flow rates may be achieved, based on application)
  • Small bench top footprint: 61 cm wide x 99 cm deep x 117 cm high (24” x 39” x 46”)
  • Easy to handle: Total weight ~ 291kg (640 lbs) - Easily movable with stainless steel casters leveling on skid with vibration isolators
  • Gamma-irradiated single-use modules
  • Scale processes up with the U2k® or down with the UFMini®
Small Footprint

The UniFuge has a small footprint.

Confidently Scale Up, Down or Out

The accurate transfer of operating protocols to the UFMini® or U2k® is streamlined as you move from early-stage development to commercial manufacturing and licensure.

Streamline Processes

Uses a sterile single-use module that is easy to install and replace after each run.


Low-shear centrifugation allows for high-quality and high-recovery separation.

Save Time

Easily incorporated into a fully-automated workflow and significantly reduces processing time.


Software and automation minimize process upsets and errors.

Minimize Contamination Risks

This single-use, closed system reduces contamination risks. It provides flexibility for multi-product facilities.


The UniFuge systems are designed to resume and recover from an interrupted process without product loss.

Cell Washing

The UniFuge systems can hold materials in the bowl for washing and buffer exchanges.


Built in a state-of-the art U.S. facility, following the highest standards of quality control.

  • Bowl capacity: 1.8 L
  • Flow rate from 1-4 L/min (higher flow rates may be achieved, based on application)
  • Processing up to 4 L/min
  • Variable speed from 300 to 4,000 x g
  • Integrated trolley
  • Designed for use at room temperatures (jackets available)
  • Optional data acquisition for SCADA System via Ethernet connection
  • cGMP-compliant 21 CFR Part 11 data trail
  • Low noise level (below 80 dB) during operation
  • Instrument built in a state-of-the-art ISO 9001 US facility, following the highest standards of quality control.
  • Fully-automated, intuitive software
  • PLC color touch screen
Single-use Modules
  • Lightweight single-use module with integral tube set
  • Predictable supply chain with multiple manufacturing facilities in the United States
  • Gamma-irradiated
  • Extractables data available
  • Compliant with ISO 11137 to SAL 10-6
  • Continuous discharge of supernatant and intermittent discharge of cell culture
  • Modules can be tube welded to single-use bioreactor connections (customer-specified single-use connectors are available upon request)
  • Reduce HCP and other contaminants
How It Works

The UniFuge is completely automated with flexible cycle parameter entry. The feed suspension is gently pumped to the module and the cells settle to the outer radius while the clear supernatant is continuously discharged. Once the module has filled with cells, the controller stops the rotor and discharges the cells. This cycle is repeated until the bioreactor volume has been processed.

Automation and General Specifications
  • Total skid weight of 291 kg (690 lbs)
  • Allen-Bradley® PLC
  • Maximum case pressure (for cooling) 6.9 bar (100 psi)
  • Center feed for low shear operation
  • Concentric tubes to introduce feed and remove supernatant
  • PCV up to 25%
Utility Requirements
  • Power configurations: 120/230 VAC, 50/60 Hz, 1 Ph, 10 A
  • Optional: 120 VAC, 50/60 Hz, 1 Ph, 20 A
  • Pneumatic: Clean, dry air supply 4.5-6.6 bar (65-95 PSI), 57 SLPM (2 SCFM)
Single-Use Module
  • 1800 mL single-use modules with 12 mm (1/2”) ID x 19 mm (3/4”) OD Silicone tubing
  • Continuous discharge of supernatant and intermittent discharge of cell culture
  • Components compliant with physiochemical tests: intermittent discharge of cell culture: USP <87> <88> Class VI, USP 661 (or ISO 10993) for plastic materials
  • Center feed for low-shear operation
  • Concentric tubes to introduce feed and remove supernatant
centrifuge-2 Single-Use Centrifuges Brochure
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