Primary Clarification of Lentiviral Vector with Low-Shear Separation

Lentiviral vectors are commonly used in the production of ex vivo cell therapies to transduce various cell types. Lentiviral vectors are sensitive to the shear forces of traditional continuous centrifugation systems. Additionally, significant yield losses due to adsorption effects can be seen during the primary clarification of lentiviral vectors with single-use filtration methods such as depth filtration.