Media Exchange in iPSC Cell Expansion and Differentiation: A Comparative Study of UniFuge® Micro and Gravity Sedimentation

This case study shares results from a provider of iPSC-based cell therapy development and manufacturing solutions that evaluated the UniFuge Micro® for media exchange during hematopoietic differentiation. The study demonstrated that UFMicro preserved aggregate morphology, supported consistent biomarker expression, and achieved up to 107% HSC yield compared to gravity sedimentation, highlighting its value in GMP-compliant workflows.

Enabling MSC Harvest, Wash, and Concentration with UFMini®

Too Much Equipment, Not Enough Room: Rethinking Capital Efficiency in Cell Processing

When cell therapy developers think about efficiency, the conversation usually centers on yield, throughput, or cost of goods. But in nearly every cleanroom we walk into, the most pressing constraint isn’t reagents or labor—it’s physical space. With limited room for equipment, teams are forced to make trade-offs: Can we get by with what we have? What else can this system do? The real question becomes how to maximize what you already have without sacrificing flexibility or performance. In this piece, we explore how capital efficiency in cell processing comes from smarter equipment choices, not just buying less. That means choosing systems that adapt to shifting workflows, support multiple unit operations, and make the most of every square foot. Based on what we’re hearing from the field, it’s time to rethink how equipment is deployed—not as fixed-function tools, but as adaptable assets that work harder for the footprint they occupy.