Stainless Steel Centrifuges
CIP and SIP-able Systems
CIP and SIP Stainless Steel Systems
Our reliable and robust stainless steel equipment addresses even the most challenging separations. Leading biopharmaceutical companies around the world rely on our machines to manufacture their licensed products. Clean-in-Place (CIP) and Sterilize-in-Place (SIP) systems can be used during product or batch changes to prevent contamination.
Powerfuge Family
- Designed for bacteria, fungi, proteins and sub-micron particles
- Proven for the production of plasmid DNA, vaccines, plasma protein, cellular agriculture and specialty chemicals
- G-forces up to 20,000 x g, the highest g force in the market
- Bowl volumes from 1.1 L to 36 L
- Flow rate from 250 ml/min to 1700 L/hr
- Solid-bowl centrifuges
- Automatic solid discharge
- SIP/CIP capabilities
- Hazardous duty option available
Viafuge Family
- Designed for mammalian, insect and plant cells
- Typical cell viability of 98% or higher
- Yield up to 98%
- G-forces up to 10,000 x g
- Bowl volumes from 1.4 L to 16.7 L
- Flow rate 2,400 L/hr
- Solid-bowl centrifuges
- Automatic centrate discharge
- SIP/CIP capabilities
Key Features
Advantages of Our Equipment
Our long history and deep expertise with pioneering separation technology allows us to deliver top-performing solutions through a reliable supply chain.
Performance
Our reliable and robust centrifuges address even the most challenging separations.
Scalability
Our equipment accommodates small process development volumes to very large commercial needs, allowing for seamless scale-up and scale-down.
Versatility
Our stainless steel centrifuges are designed to serve a variety of markets.
Stainless Steel Centrifuges
The Powerfuge® Family
Powerfuge centrifuges are well suited for separation of bacteria, fungi, proteins, and sub-micron particles. At the end of a run, compressed solids can be removed with minimal time and effort.
Powerfuge P12
Clean-in-Place / Sterilize-in-Place System
The Powerfuge P12 System is a batch liquid/solid separation system for bacteria, yeast, proteins and sub-micron particles. It is designed to provide continuous-flow two-phase separation of solids and liquids and meets cGMP and CE requirements as well as chemical and pharmaceutical industry protocols.
- Bowl capacity: 8L
- Flow rates up to 500 L/hr for batches up to 500 L
- Footprint ~ 78.7 cm wide x 172.7 cm deep x 203.2 cm high (31” x 68” x 80”)
- Total weight ~ 1924 kg (4,240 lbs)
- Fully scalable to smaller automated Pilot and P6 models
- Fully scalable to larger automated P18 model
- Drier solids and clear liquids
Performance
With g forces up to 20,000 X g, the Powerfuge addresses even the most challenging separations.
Scalability
The Powerfuge family of products can be used for small process development volumes all the way to very large commercial manufacturing, allowing for seamless scale-up and scale-down.
Versatility
The Powerfuge is designed to serve the needs of a variety of markets.
Features
- Bowl capacity: 8 L
- Flow rates up to 500 L/hr for batches up to 500 L
- Variable speeds up to 20,000 g
- Sealed automatic operation
- Full CIP/SIP designs + automated CIP/SIP cycles
- Meets cGMP and CE requirements
- Designs available for ASME-rated boundary, hazardous locations, and aseptic operations
- Continuous-flow two-phase separation
- Optional hazardous duty (Class 1, Div 1) CE configurations are available
- State-of-the-art manufacturing facility located in Clearwater, Florida USA
How It Works
Using an innovative design, the feed is introduced through a stationary pipe and accelerated to full rotational speed before entering the titanium-alloy bowl. In this system, centrifugal forces as 20,000 g permit separation of even sub-micron particles. Compressed solids are periodically removed with a fully automated scraping cycle. After the solids have been discharged, automated CIP/SIP cycles can be performed via the PLC-controlled operating sequence.
Automation and General Specifications
- Allen-Bradley® or Siemens® PLC
- Allen-Bradley or Siemens HMI touchscreen 30.7 cm (12.1”)
- Maximum case pressure (for cooling) 6.9 bar (100 psi)
Utility Requirements
- Power configuration: Single phase voltage supply:
- US: 460V/60 Hz, 45 A
- Europe: 400V/50 Hz, 46 A
- Japan: 200V/60 Hz/50 Hz, 90 A
- Optional: Others as needed
- Pneumatic: Clean, dry air supply 6 bar (90 psi) at 566 SLPM (20 SCFM)
Process Wetted Parts Construction
- 316L Stainless Steel
- 17-4 PH Stainless Steel
- Nitronic 60 Stainless Steel
- Platinum-cured silicone hoses
- EPDM elastomers
- Ti-6Al-4V Titanium
Stainless Steel Centrifuges
The Viafuge® Family
The Viafuge centrifuges are low-shear stainless steel systems designed for separation of mammalian, insect and plant cells with typical cell viability of 98% or higher.
Powerfuge P12
Clean-in-Place / Sterilize-in-Place System
The Powerfuge P12 System is a batch liquid/solid separation system for bacteria, yeast, proteins and sub-micron particles. It is designed to provide continuous-flow two-phase separation of solids and liquids and meets cGMP and CE requirements as well as chemical and pharmaceutical industry protocols.
- Bowl capacity: 8L
- Flow rates up to 500 L/hr for batches up to 500 L
- Footprint ~ 78.7 cm wide x 172.7 cm deep x 203.2 cm high (31” x 68” x 80”)
- Total weight ~ 1924 kg (4,240 lbs)
- Fully scalable to smaller automated Pilot and P6 models
- Fully scalable to larger automated P18 model
- Drier solids and clear liquids
Performance
With g forces up to 20,000 X g, the Powerfuge addresses even the most challenging separations.
Scalability
The Powerfuge family of products can be used for small process development volumes all the way to very large commercial manufacturing, allowing for seamless scale-up and scale-down.
Versatility
The Powerfuge is designed to serve the needs of a variety of markets.
Features
- Bowl capacity: 8 L
- Flow rates up to 500 L/hr for batches up to 500 L
- Variable speeds up to 20,000 g
- Sealed automatic operation
- Full CIP/SIP designs + automated CIP/SIP cycles
- Meets cGMP and CE requirements
- Designs available for ASME-rated boundary, hazardous locations, and aseptic operations
- Continuous-flow two-phase separation
- Optional hazardous duty (Class 1, Div 1) CE configurations are available
- State-of-the-art manufacturing facility located in Clearwater, Florida USA
How It Works
Using an innovative design, the feed is introduced through a stationary pipe and accelerated to full rotational speed before entering the titanium-alloy bowl. In this system, centrifugal forces as 20,000 g permit separation of even sub-micron particles. Compressed solids are periodically removed with a fully automated scraping cycle. After the solids have been discharged, automated CIP/SIP cycles can be performed via the PLC-controlled operating sequence.
Automation and General Specifications
- Allen-Bradley® or Siemens® PLC
- Allen-Bradley or Siemens HMI touchscreen 30.7 cm (12.1”)
- Maximum case pressure (for cooling) 6.9 bar (100 psi)
Utility Requirements
- Power configuration: Single phase voltage supply:
- US: 460V/60 Hz, 45 A
- Europe: 400V/50 Hz, 46 A
- Japan: 200V/60 Hz/50 Hz, 90 A
- Optional: Others as needed
- Pneumatic: Clean, dry air supply 6 bar (90 psi) at 566 SLPM (20 SCFM)
Process Wetted Parts Construction
- 316L Stainless Steel
- 17-4 PH Stainless Steel
- Nitronic 60 Stainless Steel
- Platinum-cured silicone hoses
- EPDM elastomers
- Ti-6Al-4V Titanium
Endorsements
See What People Are Saying About Our Equipment
“The explosion-proof Powerfuge closed up our solvent process for a safe and environmentally friendly manufacturing method.”
Senior Process Engineer, Pigments
“The Powerfuge closed up our ethanol process and its automatic scraping improved our recovery.”
Associate Director of Vaccine Franchise
“Removing large particles with Powerfuge reduced the number of filtration steps.”
Manufacturing Engineer, Pigments
“The high g-force of the Powerfuge [e. Coli lysate clarification] reduced our downstream clarification needs.”
Senior Process Development Scientist, pDNA
"Gentle handling of our cells at scale resulted in higher VLP recovery.”
Director of Operations, Vaccine Manufacturing
“We replaced our bottle centrifuges with a single continuous Viafuge, saving cleaning, autoclaving, and manual manipulations."
Animal Vaccine Manufacturing Operations Manager
“The UniFuge was easy to scale-up, and the Viafuge enables us to recover viable cells at large scale, beyond what single-use can typically accomplish."
Cellular Agriculture Entrepreneur
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