Stainless Steel Centrifuges
CIP and SIP-able Systems
CIP and SIP Stainless Steel Systems
Our reliable and robust stainless steel equipment addresses even the most challenging separations. Leading biopharmaceutical companies around the world rely on our machines to manufacture their licensed products. Clean-in-Place (CIP) and Sterilize-in-Place (SIP) systems can be used during product or batch changes to prevent contamination.
Powerfuge Family
- Designed for bacteria, fungi, proteins and sub-micron particles
- Proven for the production of plasmid DNA, vaccines, plasma protein, cellular agriculture and specialty chemicals
- G-forces up to 20,000 x g, the highest g force in the market
- Bowl volumes from 1.1 L to 36 L
- Flow rate from 250 ml/min to 1700 L/hr
- Solid-bowl centrifuges
- Automatic solid discharge
- SIP/CIP capabilities
- Hazardous duty option available
Viafuge Family
- Designed for mammalian, insect and plant cells
- Typical cell viability of 98% or higher
- Yield up to 98%
- G-forces up to 10,000 x g
- Bowl volumes from 1.4 L to 16.7 L
- Flow rate 2,400 L/hr
- Solid-bowl centrifuges
- Automatic centrate discharge
- SIP/CIP capabilities
Key Features
Advantages of Our Equipment
Our long history and deep expertise with pioneering separation technology allows us to deliver top-performing solutions through a reliable supply chain.
Performance
Our reliable and robust centrifuges address even the most challenging separations.
Scalability
Our equipment accommodates small process development volumes to very large commercial needs, allowing for seamless scale-up and scale-down.
Versatility
Our stainless steel centrifuges are designed to serve a variety of markets.
Stainless Steel Centrifuges
The Powerfuge® Family
Powerfuge centrifuges are well suited for separation of bacteria, fungi, proteins, and sub-micron particles. At the end of a run, compressed solids can be removed with minimal time and effort.
Viafuge ® V12
Clean-in-Place / Sterilize-in-Place System
The Viafuge® V12 is designed for fast, gentle medium- to large-scale cell harvesting and clarification. Capable of separating a wide variety of mammalian and insect cells with little to no damage, the Viafuge V12 offers high purity results with undetectable cell concentrations in clarified supernatant.
- Bowl capacity: 9.6 L or 16.7 L
- Flow rates up to 2400 L/hr for batches up to 2000 L
- Footprint: ~ 127 cm wide x 249 cm deep x 287 cm high (50” x 98 ” x 113”)
- Total weight ~ 1119 kg (2,460 lbs)
- Gentle cell harvesting and supernatant recovery
- scalableCan be scaled-down to smaller automated Pilot model
- Improved product processing
- Concentrated cells and supernatant can be recovered without breaking containment
- 20-fold concentration factor
Low-Shear Performance
The Viafuge V12’s unique design minimizes shear forces on cells, boasting a typical cell viability of 98% or higher and up to 98% yield.
Scalability
Processes developed on the Viafuge® Pilot can be seamlessly scaled to the Viafuge V12.
Features
- Bowl capacity: 9.6 L or 16.7 L
- Flow rates up to 2400 L/hr for batches up to 2000 L
- Variable speeds up to 5000 x g
- Sealed automatic operation
- Fully-automated operation
- Closed-system design with CIP/SIP
- cGMP construction
- ASME-rated designs available
- Flexible optimization
- Optional Hazardous Duty (Class 1, Div 1) CE configurations are available
- State-of-the-art manufacturing facility located in the United States
How It Works
Using an innovative design, the Viafuge V12 introduces feed through a stationary pipe, where it is accelerated to full rotational speed under low shear before entering the titanium-alloy bowl. Cells are then concentrated along a gentle path between the core and the bowl wall. The clarified supernatant is continuously discharged by gravity at atmospheric pressure. Periodically, the concentrated cells are automatically recovered from the Viafuge V12 for collection, and the cycle is repeated to process the remainder of the feed batch.
Automation and General Specifications
- Allen Bradley® or Siemens® PLC
- Allen Bradley® or Siemens® HMI touchscreen 30.7 cm (12.1”)
- Maximum case pressure (for cooling) 6.9 bar (100 psi)
Utility Requirements
- Power configuration: Three phase voltage supply:
- US: 230V/60 Hz, 20 A
- Europe: 200V/50 Hz, 20 A
- Japan: 200V/60 Hz/50 Hz, 20 A
- Optional: Others as needed
- Pneumatic: Clean, dry air supply 6 bar (90 psi) at 1 SLPM
Process Wetted Parts Construction
- USP Class VI components
- 316L Stainless Steel
- 17-4 PH Stainless Steel
- Nitronic 60 Stainless Steel
- Platinum cured silicone hoses
- EPDM elastomers
- Ti-6Al-4V Titanium
Stainless Steel Centrifuges
The Viafuge® Family
The Viafuge centrifuges are low-shear stainless steel systems designed for separation of mammalian, insect and plant cells with typical cell viability of 98% or higher.
Viafuge ® V12
Clean-in-Place / Sterilize-in-Place System
The Viafuge® V12 is designed for fast, gentle medium- to large-scale cell harvesting and clarification. Capable of separating a wide variety of mammalian and insect cells with little to no damage, the Viafuge V12 offers high purity results with undetectable cell concentrations in clarified supernatant.
- Bowl capacity: 9.6 L or 16.7 L
- Flow rates up to 2400 L/hr for batches up to 2000 L
- Footprint: ~ 127 cm wide x 249 cm deep x 287 cm high (50” x 98 ” x 113”)
- Total weight ~ 1119 kg (2,460 lbs)
- Gentle cell harvesting and supernatant recovery
- scalableCan be scaled-down to smaller automated Pilot model
- Improved product processing
- Concentrated cells and supernatant can be recovered without breaking containment
- 20-fold concentration factor
Low-Shear Performance
The Viafuge V12’s unique design minimizes shear forces on cells, boasting a typical cell viability of 98% or higher and up to 98% yield.
Scalability
Processes developed on the Viafuge® Pilot can be seamlessly scaled to the Viafuge V12.
Features
- Bowl capacity: 9.6 L or 16.7 L
- Flow rates up to 2400 L/hr for batches up to 2000 L
- Variable speeds up to 5000 x g
- Sealed automatic operation
- Fully-automated operation
- Closed-system design with CIP/SIP
- cGMP construction
- ASME-rated designs available
- Flexible optimization
- Optional Hazardous Duty (Class 1, Div 1) CE configurations are available
- State-of-the-art manufacturing facility located in the United States
How It Works
Using an innovative design, the Viafuge V12 introduces feed through a stationary pipe, where it is accelerated to full rotational speed under low shear before entering the titanium-alloy bowl. Cells are then concentrated along a gentle path between the core and the bowl wall. The clarified supernatant is continuously discharged by gravity at atmospheric pressure. Periodically, the concentrated cells are automatically recovered from the Viafuge V12 for collection, and the cycle is repeated to process the remainder of the feed batch.
Automation and General Specifications
- Allen Bradley® or Siemens® PLC
- Allen Bradley® or Siemens® HMI touchscreen 30.7 cm (12.1”)
- Maximum case pressure (for cooling) 6.9 bar (100 psi)
Utility Requirements
- Power configuration: Three phase voltage supply:
- US: 230V/60 Hz, 20 A
- Europe: 200V/50 Hz, 20 A
- Japan: 200V/60 Hz/50 Hz, 20 A
- Optional: Others as needed
- Pneumatic: Clean, dry air supply 6 bar (90 psi) at 1 SLPM
Process Wetted Parts Construction
- USP Class VI components
- 316L Stainless Steel
- 17-4 PH Stainless Steel
- Nitronic 60 Stainless Steel
- Platinum cured silicone hoses
- EPDM elastomers
- Ti-6Al-4V Titanium
Endorsements
See What People Are Saying About Our Equipment
“The explosion-proof Powerfuge closed up our solvent process for a safe and environmentally friendly manufacturing method.”
Senior Process Engineer, Pigments
“The Powerfuge closed up our ethanol process and its automatic scraping improved our recovery.”
Associate Director of Vaccine Franchise
“Removing large particles with Powerfuge reduced the number of filtration steps.”
Manufacturing Engineer, Pigments
“The high g-force of the Powerfuge [e. Coli lysate clarification] reduced our downstream clarification needs.”
Senior Process Development Scientist, pDNA
"Gentle handling of our cells at scale resulted in higher VLP recovery.”
Director of Operations, Vaccine Manufacturing
“We replaced our bottle centrifuges with a single continuous Viafuge, saving cleaning, autoclaving, and manual manipulations."
Animal Vaccine Manufacturing Operations Manager
“The UniFuge was easy to scale-up, and the Viafuge enables us to recover viable cells at large scale, beyond what single-use can typically accomplish."
Cellular Agriculture Entrepreneur
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