Single-Use Centrifuges
Benefits of Single-Use Systems
Minimize Contamination While Improving Recovery
We have been at the leading edge of single-use centrifuges for decades. Today, top biopharma companies rely on our machines to manufacture licensed products. Single-use systems leverage pre-sterilized modules to minimize contamination risks and mitigate the comparatively complex and expensive cleaning, validation, and commissioning times of traditional stainless steel centrifuges while reducing water and utility cost.
The UniFuge® family provides low-shear separation, high-recovery performance and fast processing time. With three sizes, the UniFuge enables linear scaling, providing seamless transition from benchtop process development to commercial manufacturing. The systems are easy to operate, simplifying training and requiring fewer staff than traditional centrifuges. These also have a small footprint.
- 100% closed system
- Low shear
- Clear center
- Reduce filtration needs by 85%
- Set up and change over within 15 min
- Cell viability up to 98%
- Yield up to 98%
- Confidently scale up to the U2k® or scale down to the UFMini®
- Variable speed up to 4,000 x g
- Reduce HCP and other contaminants
- GMP-compliant data trail 21cfrPart11
- Extractables data available
- SAL level 10-6
Key Features
Advantages of Single-Use Centrifuges
Easy-to-use, reliable equipment that delivers high product recovery.
Performance
Our proven low-shear technology boasts up to 98% yield and 98% or higher typical cell viability.
Scalability
Our equipment can be used from development to commercial licensure and across different reactor volumes.
Ease of Use
Our machines are rapid to install and simple to operate.
Small Footprint
Our single-use centrifuges have a small footprint.
The UniFuge Family
Our Single-Use Centrifuges
The scalable UniFuge family of centrifuges has a variable g-force up to 4,000 x g. They employ gamma-irradiated sterile single-use modules, reducing the risk of contamination.
Endorsements
See What People Are Saying About Our Equipment
“The U2k was fairly simple to use and scales nicely from the UFMini and UniFuge.”
Cell Therapies Bioproduction Expert
“The UniFuge line is simpler and required less calibration than other solutions we have tried.”
Protein Separation Bioproduction Expert, CHO
“This really opens the door with the potential to go above 300 L.”
mRNA and pDNA Bioproduction Expert
“The 20L/min flow rate is great for harvesting from 1,000-2,000 L+ bioreactors. Processing ~1,000 L/hr is very helpful for our operators. It would save a significant amount of time.”
mAb Bioproduction Expert
“The UniFuge line is easy to scale-up to the U2k or down to the UFMini.”
mAbs Bioproduction Expert
“The UniFuge was fairly simple to use and scaled nicely from the UFMini.”
Cell Therapies Bioproduction Expert
“The UniFuge has higher g forces and flow rates [compared to competitive offerings].”
Viral Vector Bioproduction Expert, HEK
“The UniFuge had the shortest processing time versus Ksep.”
Protein Separation Bioproduction Expert, CHO
“The UniFuge line is simpler and required less calibration than other solutions we have tried.”
Protein Separation Bioproduction Expert, CHO
"The UniFuge is scalable, easier to operate, and my process yield is better than using depth filters."
Protein Separation Bioproduction Expert, CHO
"This one is perfect. This would reduce our harvest time significantly. I think it fits well into the needs for a Phase III trial."
Cell Therapy Bioproduction Expert
“The explosion-proof Powerfuge closed up our solvent process for a safe and environmentally friendly manufacturing method.”
Senior Process Engineer, Pigments
“The Powerfuge closed up our ethanol process and its automatic scraping improved our recovery.”
Associate Director of Vaccine Franchise
“Removing large particles with Powerfuge reduced the number of filtration steps.”
Manufacturing Engineer, Pigments
“The high g-force of the Powerfuge [e. Coli lysate clarification] reduced our downstream clarification needs.”
Senior Process Development Scientist, pDNA
"Gentle handling of our cells at scale resulted in higher VLP recovery.”
Director of Operations, Vaccine Manufacturing
“We replaced our bottle centrifuges with a single continuous Viafuge, saving cleaning, autoclaving, and manual manipulations."
Animal Vaccine Manufacturing Operations Manager
“[The UniFuge line] is scalable, easier to operate, and my process yield is better than using depth filters.”
Protein Separation Bioproduction Expert, CHO
“The UniFuge was fairly simple to use and scaled nicely from the UFMini.”
Cell Therapies Bioproduction Expert
“UniFuge has higher g forces and flow rates [compared to competitive offerings].”
Viral Vector Bioproduction Expert, HEK
“The UniFuge had the shortest processing time versus Ksep.”
Protein Separation Bioproduction Expert, CHO
“The UniFuge line is simpler and required less calibration than other solutions we have tried.”
Protein Separation Bioproduction Expert, CHO
“The UniFuge was easy to scale-up, and the Viafuge enables us to recover viable cells at large scale, beyond what single-use can typically accomplish."
Cellular Agriculture Entrepreneur
“My biggest reason to avoid centrifuges has been that they don’t scale down, so process development is hard, and clean-in-place is a pain. [UniFuge] neatly addresses both.”
Viral Vector Gene Therapy Bioproduction Expert
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