Optimizing Washing Efficiency in Cell Washing & Media Exchange for Cell Therapy Manufacturing

This case study highlights how CARR Biosystems’ UniFuge® single‑use centrifuge systems enable highly efficient, closed‑system cell washing and media exchange for cell therapy manufacturing. Traditional manual washing methods are time‑consuming, labor‑intensive, and increase contamination risk, making them poorly suited for scalable allogeneic cell therapy production. Using the UniFuge Pilot and UFMini®, manufacturers can integrate buffer flushing and media exchange within one aseptic system, reducing process time while maintaining cell viability and recovery. Performance data demonstrate high washing efficiency across a range of G‑forces and flow rates, with optimized conditions achieving greater than 98% cell retention per wash cycle. These results show that a single‑use centrifuge can successfully combine cell harvesting, washing, and media exchange into one closed, scalable process, supporting safer, faster, and more cost‑effective cell therapy manufacturing.

UniFuge® Platform for Biologics Manufacturing

Accelerating the Seed Train: How UniFuge® Enables N-1 Intensification

Accelerate N‑1 perfusion intensification with UniFuge®. Explore closed, low‑shear cell concentration and media exchange at high density to streamline seed trains and boost upstream productivity.